Medical mycology and the chemistry classroom: Germinating student interest in organic chemistry
Bliss J.M.; Reid C.W.
2013
Journal of Chemical Education
1
10.1021/ed300482s
Efforts to provide active research context to introductory courses in basic sciences are likely to better engage learners and provide a framework for relevant concepts. A simple teaching and learning experiment was conducted to use concepts in organic chemistry to solve problems in the life sciences. Bryant University is a liberal arts university with new programs in biological and environmental sciences. This laboratory exercise was developed for introductory organic chemistry and designed to highlight its applicability to the biological sciences. Students participated in an ongoing project to identify antigens on the surface of Candida albicans hyphae by testing a variety of lipid extraction procedures and characterizing the fatty acid and carbohydrate composition of their extractions by thin-layer chromatography and gas chromatography-mass spectrometry. Student extracts were also tested in an immunoblot assay with a specific antibody fragment (scFv) that recognizes an unknown component of the cell surface of C. albicans hyphae. In order to build communication skills, students were required to prepare and present posters detailing the project and their findings. © 2013 The American Chemical Society and Division of Chemical Education, Inc.
Applications of Chemistry; Biochemistry; First-Year Undergraduate/General; Hands-On Learning/Manipulatives; Inquiry-Based/Discovery Learning; Interdisciplinary/ Multidisciplinary; Organic Chemistry; Second-Year Undergraduate; Upper-Division Undergraduate
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