CHI TIẾT NGHIÊN CỨU …
Tiêu đề
Developing a project-oriented introduction to neuroscience lab at Hope College
Tác giả
Chase L.A.; Barney C.C.
Năm xuất bản
2009
Source title
Journal of Undergraduate Neuroscience Education
Số trích dẫn
1
DOI
Liên kết
Tóm tắt
The Introduction to Neuroscience course at Hope College includes a three-hour laboratory period each week. Seven of the fifteen weeks of the lab are used for a lab project that is focused on understanding the effects of gonadal hormones on brain and behavior. Students perform ovariectomies and implant sham, estradiol, or testosterone capsules in rats and then carry out five experiments: 1) Sexual Behavior, 2) Spatial Learning using the Morris Water Maze, 3) The Size of the Sexually Dimorphic Nucleus, 4) Phosphorylation of NMDA Receptors, and 5) Long Term Potentiation in Hippocampal Slices. The experiments are designed to provide the students with experiences at different levels of neuroscience, while improving their skills in statistics, using the primary literature, and scientific writing. The students generate interesting and statistically significant data which they summarize in a journal style lab reports. Using a Self Assessment of Learning Gains tool, we learned that students perceive the lab project improves their ability to A) pose questions from more than one disciplinary perspective that can be addressed by collecting and evaluating scientific evidence, B) learn about complex science problems that require insight from more than one discipline, C) extract main points from a scientific article and develop a coherent summary, and D) write reports using scientific data as evidence. Based on our results, we believe an extended lab project in an introductory neuroscience course can be used to engage students in neuroscience topics and help them develop the skills and habits of neuroscientists. © 2009 Faculty for Undergraduate Neuroscience.
Từ khóa
Hippocampal slice; Introductory neuroscience course; Lab project; Liberal arts college; Long-term potentiation; NMDA receptor phosphorylation; Ovariectomy; Self assessment of learning gains; Sex behavior; Sex steroids; Sexually dimorphic nucleus; Spatial learning
Tài liệu tham khảo
Bish J.P., Schleidt S., Effective use of computer simulations in an introductory neuroscience laboratory, J Undergrad Neurosci Ed, 6, (2008); Chase L.A., Stewart J., Barney C.C., Cultivation of an interdisciplinary, research-based neuroscience minor at Hope College, J Undergrad Neurosci Ed, 5, (2006); Gorksi R.A., Harlan R.E., Jacobson C.D., Shryne J.E., Southam A.M., Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat, J Comp Neurol, 193, pp. 529-539, (1980); Goyette S.R., DeLuca J., A semester-long student-directed research project involving enzyme immunoassay: Appropriate for immunology, endocrinology, or neuroscience courses, CBE-Life Sci Ed, 6, pp. 332-342, (2007); Hall A.C., Harrington M.E., Experimental methods in neuroscience: An undergraduate neuroscience laboratory course for teaching ethical issues, laboratory techniques, experimental design, and analysis, J Undergrad Neurosci Ed, 2, (2003); Kuehn R.E., Beach F.A., Quantitative measurement of female sexual receptivity in rats, Behaviour, 21, pp. 282-299, (1963); McLean R.J.C., Original research projects as a major component of an undergraduate microbiology course, J Coll Sci Teach, 29, pp. 38-40, (1999); Mulder G.B., Pritchett K., The Morris water maze, Contemp Top Lab Anim Sci, 42, pp. 49-50, (2003); Leonard W.H., How do college students best learn science? An assessment of popular teaching styles and their effectiveness., J Coll Sci Teach, 29, pp. 385-388, (2000); Rosenblum K., Berman D.E., Hazvi S., Lamprecht R., Dudai Y., NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex, J Neurosci, 17, pp. 5129-5135, (1997); Sundberg M.D., Moncada G.J., Creating effective investigative laboratories for undergraduates, Bioscience, 44, pp. 698-704, (1994); Switzer P.V., Shriner W.M., Mimicking the scientific process in the upper-division laboratory, Bioscience, 50, pp. 157-162, (2000); Woodhull-McNeal A.P., Project labs in physiology, Am J Physiol, 263, (1992); Wyttenbach R.A., Johnson B.R., Hoy R.R., Crawdad: A C.D-R.O.M Lab Manual for Neurophysiology., (1999)
Nơi xuất bản
Davison College
Hình thức xuất bản
Article
Open Access
Nguồn
Scopus